Insertions and Deletions Target Lineage-Defining Genes in Human Cancers
نویسندگان
چکیده
منابع مشابه
Insertions and Deletions Target Lineage-Defining Genes in Human Cancers
Certain cell types function as factories, secreting large quantities of one or more proteins that are central to the physiology of the respective organ. Examples include surfactant proteins in lung alveoli, albumin in liver parenchyma, and lipase in the stomach lining. Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and ind...
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In this review, we focus on progress that has been made with detecting small insertions and deletions (INDELs) in human genomes. Over the past decade, several million small INDELs have been discovered in human populations and personal genomes. The amount of genetic variation that is caused by these small INDELs is substantial. The number of INDELs in human genomes is second only to the number o...
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We investigate two generalizations of insertion and deletion of words, that have recently become of interest in the context of molecular computing. Given a pair of words (x, y), called a context, the (x, y)-contextual insertion of a word v into a word u is performed as follows. For each occurrence of xy as a subword in u, we include in the result of the contextual insertion the words obtained b...
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ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.12.025